Advanced ChemTech is a leading manufacturer of resins for peptide and combinatorial synthesis. We supply these resins in gram to kilo quantities in various substitution levels, mesh sizes, and cross-linking agents. We also supply base resins, synthesis resins, and pre-loaded resins. We are continuously adding new resins to our already extensive line so please visit our website to stay up to date on new products.Our high quality resins meet or exceed our strict quality standards. Their identity is confirmed by comparing the FTIR spectrum of the resin with the standard spectra. Our resins are examined to be sure that they are free of fines and broken beads. Advanced ChemTech also measures the swelling properties and loss on drying. All resins come with a Certificate of Analysis. Advanced ChemTech’s pre-loaded resins have many advantages. They are endcapped with acetate after loading resin to reduce the possibility of first amino acid deletion impurities. In resins that are susceptible to dipeptide formation, a sample is cleaved and analyzed by HPLC to determine the extent of dipeptide formation. Epimerization during coupling is also measured by recoupling of the same amino acid, followed by cleavage and HPLC analysis of the potential diastereomers.

Peptide chemists are constantly searching for methods that improve the efficiency of coupling reactions. Higher efficiencies will enable higher quality products to be produced. Higher quality will translate to higher yields and potentially lower costs. Higher efficiencies will also increase the practical limit to the size of peptides that can be produced in the laboratory.

Two areas of concern for the peptide chemist when discussing coupling efficiency are reaction speed and racemization of the amino acid being coupled. The exploration of the reaction kinetics and mechanisms has led to the development of an array of coupling agents and coupling additives that moderate the coupling reaction such that reasonable reaction times with acceptable racemization levels are achieved.

Today, chemists engaged in the synthesis of peptides have a number of compounds that enable the customization of reaction conditions. Advanced ChemTech can provide Coupling Agents and Additives to meet the needs of your most complex peptide challenges.